federal law prohibits the administration of this preparation to animals that produce food or that are intended for consumption as food. this drug is not to be administered to horses that are to be slaughtered for use in food. Nitrofurazone (INN, trade name Furacin) is an antimicrobial organic compound belonging to the nitrofuran class. It is most commonly used as a topical antibiotic ointment. [2] It is effective against gram-positive bacteria , gram-negative bacteria , and can be used in the treatment of trypanosomiasis. Rockville, Md. - FDA is ordering the prohibition of extra-label use of topical nitrofuran animal and human drugs in food-producing animals. Mounting evidence that extra-label use of topical nitrofuran drugs in food-producing animals may produce unsafe carcinogenic residues led to the FDA ruling. Residues from pharmacologically active substances can be present in food from animals treated with veterinary medicinal products (VMPs) prior to slaughter, sampling of milk, eggs and honey. Nitrofurans are among the drugs for which extra-label use is prohibited in food animals in the USA. Nitrofurantoin The mechanism of action of nitrofurantoin is unique. INDICATION: Nitrofurazone Ointment is a water-soluble antibacterial ointment for the prevention or treatment of surface bacterial infections of wounds, burns, and cutaneous ulcers. For use only on dogs, cats and horses (not for food use). While the topical applications of the nitrofuran products are OTC, they are only approved for dogs, cats and horses (i.e., non-food producing animals); they are not intended for food and thus cannot be used in food animals. Absolutely, no extra-label use of the nitrofurans is permitted in any food animals, including seafood. For Peer Review Only A study of the kinetics of semicarbazide and nitrofurazone in chicken eggs and egg powders Journal: Food Additives and Contaminants Why semicarbazide (SEM) is not an appropriate marker for the usage of nitrofurazone on agricultural animals Richard H. Stadlera*, Ludovica Verzegnassib, Walburga Seefelderc and Lucie Racaultd ing their extI2label use in food animals illegal Veterinarians violating state or federal laws regu- lating the transpon, sale, or use of drugs may face var-.